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A Beginner’s Guide to Tianeptine: Everything to Know

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Imagine waking up feeling fresh. You’re ready to face the day. Your mood is good, the weight of stress feels lighter, and it doesn’t take effort to lift the brain fog and feel alert. You don’t remember the last time you felt this way.

Have you longed for this feeling? 

Many prescription anti-depressant drugs offer this promise, but they can take a long time to kick in and they have too many side-effects and drawbacks: sexual dysfunction, sleep problems, weight change, fatigue, etc.

Gaining access to these sorts of drugs also requires getting a prescription in the first place, a hefty investment of time and money. Plus, not everyone suffering from brain fog or anxiety qualifies for clinical intervention.

Thankfully, there’s a simpler solution – a nootropic that has been clinically demonstrated to provide similar positive effects to prescription anti-depressants with fewer and less frequent side effects.

In this article, the Beginner’s Guide to Tianeptine, we’ll tell you everything you need to know about one of the most effective nootropics for dealing with anxiety and depression.

What is Tianeptine? 

The opioid tianeptine was discovered by the French Society of Medical Research in the 1960s.

It is classified as an atypical anti-depressant because it does not function in the same way as the classic categories of anti-depressants, such as selective serotonin reuptake inhibitors (SSRIs) and tricyclic anti-depressants (TCAs). 

In fact, despite decades of research, experts are still uncertain exactly how tianeptine works. What they have found, however, is that it is effective at treating symptoms of anxiety and depression.

It is one of several nootropics that are growing in popularity for improving mental health

Tianeptine has been marketed under various brand names around the world, most commonly Stablon and Coaxil. Though the FDA has yet to approve it for medical use in the US, it has been used as an anti-depressant in Europe, Asia, and Latin America.

Benefits of Tianeptine

There are numerous documented benefits of tianeptine. The primary benefits relate to anxiety and depression symptoms, but the nootropic also has positive effects on asthma, irritable bowel syndrome, and cognitive abilities involved in memory and learning.

It has been hailed by some researchers as a potential breakthrough in the treatment of depression.

It’s important to point out that even if you don’t suffer from clinical depression or anxiety, you can still benefit from tianeptine. Who can’t do with improved mood, reduced stress, and more mental clarity?


One of tianeptine’s most exciting and unique effects is an immediate improvement of your mood. While clinical anti-depressants can take weeks to take effect, tianeptine can have an impact as soon as you take it. 

These effects are sustainable. Studies have shown that extended treatment with tianeptine reduces the symptoms of depression and helps prevent relapse.

In addition to generalized relief of depression symptoms, it can specifically help people suffering from depression due to chronic alcoholism or the onset of menopause.


Treatment with tianeptine can also improve symptoms of anxiety and reduce the cognitive impacts of stress. It even helps prevent the effects of post-traumatic stress disorder.

Other Benefits

Tianeptine can prevent asthma attacks and can be as effective as standard drugs at treating irritable bowel syndrome. Perhaps the most interesting added effects, however, are the ones affecting memory and learning.

Some of the demonstrated positive impacts of tianeptine on memory and learning are reasoning ability, immediate verbal memory, and delayed memory. 

It can also improve motivation, focus, attention, and even reaction time.

Types of Tianeptine: Which One Should I Take?

Tianeptine comes in three different forms: sodium, sulfate, and free acid. All three share the same active ingredient, so you’ll get the same effects from any of them. The question is: How do you decide which to take?

The difference between the three types is the way that the body absorbs them. Choosing which form you prefer depends on what you’re looking to get out of it.

Tianeptine Sodium

Salts (sodium) are often used in medications intended to have a quick effect. Because of the weak chemical bonds in salts, they break down easily in the body. 

Thus, of the three types, your body will process tianeptine sodium the quickest – it can impact you mere minutes after taking it.

This quick action means that the sodium form will affect you the fastest. The downside is that it will only last for a few hours before wearing off. You may also notice feeling of coming down.

If you’re looking for a quick-acting mood booster to use as needed, tianeptine sodium may be the type you want.

Tianeptine Sulfate and Tianeptine Free Acid

The chemical makeup of the sulfate and free acid forms are less readily processed by the body. The molecules the tianeptine are bound to must be processed by the liver before they can take effect.

Because these types break down more slowly in the body, they create a gentler and more sustained effect. These may take a couple of hours to kick in, but they can last all day.

This is ideal for someone planning on everyday use. 

If you want a smoother experience and you’re looking for longer-lasting effects, try the tianeptine sulfate or free acid.

How Does Tianeptine Work?

The pharmacology of tianeptine is unusual for an anti-depressant. While drugs like SSRIs work by preventing the reabsorption of serotonin in the brain, tianeptine appears to increase this reabsorption. 

This isn’t the full story, though. Tianeptine affects the body’s levels of glutamate and the functioning of its receptors in a unique way. 

Glutamate plays an important role in the way that the brain and the body operate. It affects cognitive abilities, memory development, and neural plasticity. Problems arise when glutamate levels are too high or too low.

Normalizing glutamate levels and the operation of its receptors in the brain is thought to be the main way that tianeptine functions.

This glutamate regulation combines with its effects on other neurotransmitters. This makes it very effective at improving mood and protecting the brain against the effects of stress.

Is Tianeptine Safe?

You should discuss any change in your supplementation practice with a medical professional. That said, tianeptine is typically easier on the system than clinical anti-depressants. 

Tianeptine should only be taken orally. Sublingual application of any form of the nootropic can damage your mouth. 

Snorting or smoking the substance constitutes abuse and can quickly cause adverse effects or lead to addiction.


It is important to pay close attention to recommended dosages. If you’re taking tianeptine sodium, you shouldn’t exceed 300mg per day or 100mg in one dose.

You should also begin with lower doses to find your threshold. Starting with 12.5mg three times per day is recommended.

For tianeptine sulfate and free acid, you should start with a dosage of 20mg twice per day. Don’t exceed 100mg per day with these types.


As with any substance, tianeptine can be unhealthy if used irresponsibly. Maintaining the lowest necessary dosage to feel the desired effects is important. Overuse can lead to tolerance and physical addiction.

When using tianeptine, it is necessary to adhere to a dosage schedule that works for you. If you or someone you know is struggling with addiction to it or any opiate, contact a physician. 

It is possible to wean off of tianeptine and other anti-depressants, but it should be done under the supervision of a medical professional.


Like other forms of anti-depressant, tianeptine can have adverse effects in people suffering from bipolar disorder. 

Adolescents and pregnant women especially should consult with their physician before taking tianeptine.

Legal Status

Tianeptine has varied legal status around the world, but it is generally available online.

In the United States, it is uncontrolled with the exception of the state of Michigan, where it has been classified as a Schedule II controlled substance.

In most other countries, it is either available by prescription or unregulated. Check your local regulations to ensure its availability in your country.

Is Tianeptine For Me?

Given the plethora of benefits outlined in this guide to tianeptine, it’s clear that it can be helpful to a wide variety of people. As a mood enhancer and stress reliever that can help improve your motivation and focus, anybody could stand to benefit from it.

Tianeptine can be of particular value to individuals who experience depression or anxiety issues. If you fall into this category, consult with your physician to see if it could work for you.

If you’re interested in safely purchasing tianeptine or learning about the benefits of other nootropics, shop or read more on our site.

Beginners, Nootropics, Tianeptine

These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.

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