How to Determine the Proper Tianeptine Dosage
If you’re wondering how to determine the appropriate Tianeptine dosage for your needs, you are in the right place. Even though all people are built differently, there is a recommended dosage to avoid most side-effects.
In essence, the dosage protocol consists of three principles.
First, you don’t abuse Tianeptine because you no longer feel the effects. Second, you don’t consume all of the daily limits at once. Third, you do consult with a medical specialist beforehand.
In this article, we will cover everything you need to know about Tianeptine, as well as how to dose your consumption. So that you can ensure your health and wellbeing when reaping the benefits of this substance.
Whenever you’re ready to take your health in your hands and determine if Tianeptine is right for you, keep reading.
What Is Tianeptine?
Tianeptine, also known as Coaxil or Stablon is a pharma-grade compound that’s used in clinical depression treatment. It’s sometimes used for mitigating symptoms of irritable bowel syndrome and asthma.
At big doses, tianeptine has an opioid-like reaction, such as motivation, stimulation, sedation, and euphoria. In terms of class, it’s a tricyclic antidepressant.
Nonetheless, its effect very different from a traditional antidepressant or anxiolytic. Mostly in the fact that it does not act instantly through monoaminergic neurotransmitters, such as dopamine, serotonin, and noradrenaline.
But it acts on the glutamate and glutamatergic mechanisms, causing the adaptation to stress and depression. In clinical settings, it’s used as an alternative to effective antidepressants, such as fluoxetine and amitriptyline. Beyond that, it exhibits fewer complications and side effects.
Many studies have revealed that tianeptine does in fact modulate neurochemical processes. According to current models, the tianeptine mechanisms of actions are:
- Enhanced serotonin cell uptake
- Activation of mu-opioid receptors
- Modulation of glucocorticoid receptors
- Upregulation of inhibitory GABA in the spinal cord
- Activation of adenosine A1
- Regulation of hypothalamic-pituitary axis and prefrontal cortex
Tianeptine does have strong anxiolytic properties, showing promise in panic disorder treatment. Tianeptine also affects neuroprotective and cognitive brain functions. Considering these effects, tianeptine has become a popular nootropic.
Tianeptine Sodium vs Tianeptine Salts
Like any other drug, Tianeptine can come in many forms. These forms have their own effectiveness, bioavailability, and absorption. Tianeptine can be found in sodium salt form because the version is that which is prescribed by doctors and sold in pharmacies.
But, Tianeptine Sulfate is the marketed nootropic version, proposing its superiority. In essence, there is no practical data on improve efficacy, but there are anecdotal comments that suggest otherwise for stronger effect and longer duration.
The sulfate form is not especially anymore potent, but it’s slowly metabolized in comparison, meaning the dose will be effective throughout the entire day. Anecdotal comments mention that slow stabilization contributes to decreased addiction potential.
The sulfate form is bound to provide a balanced experience, as opposed to sodium salts, which are known to peak in effects for antidepression but rebounds to baseline in moments.
Pharmacology & Method Of Action
Unlike most antidepressants that are prescribed, Tianeptine has practically no interaction with monoamines, such as dopamine or serotonin. It does increase levels of extracellular dopamine, but the method behind this is unknown.
In animal studies, Tianeptine does not increase serotonin. It has been noticed to increase the reuptake of Serotonin, which is interesting because most antidepressants are reuptake inhibitors. The serotonin alteration via Tianeptine is not relevant to pharmacology
Unlike many of the prescribed antidepressants, tianeptine has practically negligible interaction with the monoamines, such as serotonin and dopamine. It does increase the extracellular levels of dopamine, but the exact method of action for this process is unknown.
In rat studies, it has been noted that tianeptine does not increase serotonin levels. Rather, it has been noted that it increased the reuptake of the neurotransmitter, which is interesting considering that most antidepressants are reuptake inhibitors. Nonetheless, the alteration of serotonin via tianeptine is most likely not relevant to pharmacology.
Tianeptine plays a big role in neuroplasticity via glutamate modulation and receptor associations, primarily via NMDA receptacle regulation.
In-Depth Look Of Each Method
For stabilization of glutamate, studies have shown that Tianeptine regulates glutamatergic receptors in different brain locations. It can prevent stress-induced increases in the amygdala, which is responsible for the regulation of fear, reward, and emotion.
Thus, balancing this activity within the amygdala can regulate the mood. Tianeptine can prevent aberrant glutamatergic vesicle reorganization at the synapse. This shows that it can protect against stress pathologies on an anatomical level.
The excitatory-inhibitory (GABA-glutamate) balance is important for brain health. Dysregulation of these will lead to a psychiatric disorder.
For boosts of serotonin uptake, Tianeptien helps neurons soak up extracellular neurotransmitter, balancing the deficits and increasing hte levels of intracellular serotonin. Serotonin is often decreased in individuals with depression.
For adenosine receptors, Tianeptine activates the A1 subunit. This helps with anxiety because the activation of these receptors leads to decreased heart rate. A heart rate decrease lowers panic and anxiety symptoms without the removal of emotion and internal thought.
Tianeptine also aids in the regulation of brain-derived neurotrophic factor, which is critical to neuronal growth, synaptic plasticity, and survival. All studies have shown chronic and acute stress decreased BDNF.
Tianeptine can rescue the phenotype. Because BDNF is critical to the function of synapses, their stabilization, and plasticity, this is a mechanism that underlies the improvements in memory, learning, and cognition.
Neuroplasticity changes are linked to reductions in stress and depression. Recent studies show that Tianeptine can act as an μ-opioid receptor agonist, which contributes to anxiolysis.
Tolerance & Addiction
It’s quite well-known that chronic use of Tianeptine is somewhat addictive. It can cause both physical and psychological dependence. When the physical part develops, withdrawal symptoms are to occur if they stop usage.
Tolerance to the effect spectrum will also develop over chronic use, including the therapeutic effects. This is what pushes people to take greater doses to get the same kind of effect.
It takes about a week for tolerance to split in half, while it takes about 2 weeks to baseline. Tianeptine also has come cross-tolerance with other antidepressants in the tricyclic category.
Because of the short-lasting effects of Tianeptine, it contributes to the compelling nature of redosing. The euphoric effects of large dosing will cause some individuals to go over advised amounts, this intensifies the side-effects and develops tolerance.
Because of the μ-opioid receptor agonist properties, Tianeptine might have withdrawal addiction tendencies like any other opioid. However, like anybody looking to stop using their medication, daily users of this compound should slowly taper their doses and not stop immediately. This will ensure that side-effects of discontinuation are minimized severely.
The withdrawal is nothing but unpleasant. It can occur at the smallest of doses, even at 500mg each day. However, the severity of the withdrawal will increase with quantity and length of use. Some of the symptoms are flu dry heaves, watery eyes, emotional disturbance, and breath instability.
Some believe that Tianeptine withdrawal is worse than a traditional opioid. And that might actually be the case, because of the collective effects of the various methods of action.
The next thing to consider is the legality of this substance. Tianeptine is commonly available by prescription in Asian, European, and South American countries. It can be found under the name of Stablon or Coaxil.
In the UK, Tianeptine is uncontrolled, but it’s not legal to supply, import, or produce it. It can be in your possession without a license or prescription. In Switzerland, it’s not the controller. The legal status is dependent on the circumstance.
In Germany, it’s a prescription medication. In Russia, it’s a controlled substance of Schedule III. In the US, Tianeptine is uncontrolled. Nonetheless, many vendors do not provide this substance because of the potential abuse and recreational use.
In the state of Michigan, it’s a controlled substance under Schedule II. In any case, wherever you are, you should consult your local authorities to ensure the law is not being broken. If tianeptine is federally controlled, the consequences and charges will be serious.
How to Take Tianeptine Safely?
Tianeptine should only be taken orally. Sublingual administration is to be avoided because the salts can damage your skin in the mouth. If you use the sulfate form, you can develop a tongue infection.
Tianeptine has a very strong acid profile, which is responsible for yeast growth in such situations. Smoking or snorting the substance in any form should not be done ever. Abuse is very real and is not encouraged.
If you’re wondering about taking it without or with food, you should take it at least 30 minutes before your meal to ensure the digestion is not depreciated. Also, don’t take any more than 100mg peruse, and 300m throughout the day.
The dosage will vary for each person greatly. Typically, 40mg is enough for most people to feel the effects. Because of the longer onset, the substance is used in therapeutic situations. Doctors might choose to prescribe the substance for long-term treatment of depression.
For tianeptine sodium, the dosage is a bit different. 15mg is more than enough to start feeling the effects for most people. It’s also important to mention that dosages higher than 80mg will start to produce opioid effects.
In those with bipolar symptoms and depression, the substance will worse the depression-mitigation outcomes. Tianeptine in women with pregnancy will cause neonatal abstinence. Tianeptine also contributes to binge-drinking in younger individuals, but the reverse is seen for grown individuals.
The Recommended Tianeptine Dosage
In our opinion, the best Tianeptine dosage is 12.5mg per session, at a maximum of 3 administrations per day. It’s recommended that you split your Tianeptine into separate quantities because the drug has a very short half-life.
This means that it will only be half as potent after two hours due to quick metabolization. Tianeptine can cause severe euphoria when consumed recreationally. It’s sensible that you don’t use this substance recreationally because of the potential for abuse and risk.
If you are consuming any other type of medication or dealing with a serious mental health issue, you must speak to your medical specialist before considering administration.
Tianeptine can worsen all symptoms of depression in some complex disorders, such as bipolar. Since the drug has a similar effect profile as opioids, people who have struggled with abuse in the past should avoid Tianeptine.
Breast-feeding or pregnant women should avoid Tianeptine due to opioid effects as well. Tianeptine should also be avoided by individuals under 18 years of age, preferably 21 (unless prescribed by a doctor). Tianeptine can envelop and cause serious mental inefficiency and loss of cognition in individuals who permit chronic use of the substance.
Unfortunately, younger individuals are more likely to use Tianeptine chronically, so it’s best to avoid this substance until the later stages of life.
Buy Tianeptine Now
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