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Tianeptine Review: Stablon and Coaxil

tianeptine review

Tianeptine has many names, two of which are widely known. If you’ve heard of Coaxil or Stablon, you’ve heard of tianeptine – but hearing about something does not constitute knowing about it. In essence, tianeptine is a popular alternative to tricyclic antidepressants, but that’s not the only reason people use it. The compound is quite infamous in the nootropic communities for treating serious disorders. In this tianeptine review, we will cover everything you need to know about the substance, so that you can decide if you would like to try it for yourself.

Whenever you’re ready to delve into the world of powerful medicines, keep reading.

What Is Tianeptine: Coaxil and Stablon?

Tianeptine is a chemical compound known under the names of Stablon and Coaxil. It is used to treat major depressive disorder among other conditions. For example, tianeptine is effective against asthma and irritable bowel syndrome.

Tianeptine has anti-anxiety and antidepressant qualities with a variety of other bodily effects. Some of them are anxiety suppression, euphoria, but also rejuvenation and motivation enhancement.

Tianeptine was patented in the 1960s by the French Society of Medical Research.

Some other previous names for tianeptine are Tatinol, Tianeurax, Salymbra. Tianeptine is readily available in many Asian, European, and South American countries.

But it is a scheduled drug in the UK and is not prescribed by doctors in the US. Mostly due to the potential of recreational abuse and addiction.

Tianeptine challenges the monoaminergic depression hypothesis. As well as the assumed mechanism whereby the action of most medications is known. However, nobody is sure of how tianeptine works in the conditions mentioned earlier.

The potential mechanisms will be reviewed later. For now, let’s take a look at the efficacy of tianeptine for some prominent disorders. If you ever get prescribed tianeptine, follow the treatment guidelines to the tee.

Do not discontinue the medication abruptly. Don’t adjust your dose without consulting your medical specialist.

Treatment of Depression With Coaxil/Stablon

Stablon/Coaxil is quite comparable to tricyclic antidepressants in the treatment of major depression or dysthymia disorder. Consequently, extended treatment with Coaxil/Stablon decreases the likelihood of disorder recurrence.

In Parkinson’s’ trials, the compound depleted the severity of depression. Thus, resulting in improved quality of life for patients. In animal trials, the compound decreased drug-induced seizures and improved learning capacity. 

Tianeptine has use in the treatment of depressed patient subgroups. These are, but not limited to chronic alcoholics or the elderly. It does not result in any cardiovascular or anticholinergic side effects.

Tianeptine is also effective for symptoms of depression in postmenopausal women. It does not affect long-term weight. It should not have use in the treatment of obesity via appetite reduction.

Treatment of Anxiety, PTSD, And Stress

Tianeptine improves the objective and subjective neurocognitive functions. As well as improves symptoms of anxiety.

In trials, tianeptine appears to reduce the reactivity of patients to panic challenges. In other studies, it is more effective in PTSD than the control group.

In rat trials, tianeptine was able to prevent psychosocial stress for predator-originating PTSD. It also prevents morphine-induced respiratory depression and improved respiration.

Tianeptine is also capable of improving memory and extinction learning. Thus, tianeptine can potentially change learning behavior in exposure therapy systems.

Because of the memory-protective qualities, tianeptine blocks the stress effects on hippocampus learning. This is subject to support by the blockage of stress-induced memory errors. 

In maternally deprived rats subjected to field tests, tianeptine assisted them in coping with stress. This decreases their immobility timing.

In female rats, tianeptine reduced the adverse effects of lipopolysaccharide on BDNF levels. With results, better than fluoxetine or desipramine (traditional antidepressants).

Along with similar drugs, tianeptine helps restore the biomolecule damage caused by stress. Tianeptine also reverses the decrease in catalase activity. That which is often be caused by saline administrations.

For the final stress-related treatment, tianeptine lowers stress-related hair loss.

Improvement in Learning and Memory

Clinical trials comparing tianeptine and escitalopram on major depression exist. Patients were randomly assigned the medications. After several weeks, the group consuming tianeptine showed great improvement in verbal memory.

But also in delayed memory, commission error, reasoning capacity, and mini-mental state examination. When compared against the SSRI group, there was an improvement. Primarily, in reasoning and delayed memory but nothing else.

Treatment of major depression with tianeptine leads to improvement in neurocognitive function.

It’s known to exert improving qualities on learning. As well as reference memory and exhibits vigilance-enhancement on monkeys and rats.

A tacrine and tianeptine hybrid were quite promising. It was used for the treatment of Alzheimer’s disease in cellular models.

However, never consider single trials and animal research to be conclusive. Reserve judgments until further research appears. 

Treatment of Irritable Bowel Syndrome

In the intestinal tract, directly affecting the nervous system, serotonin plays an important role.

Not only does it control the movement of digestive material. But it also controls intestinal secretion.

Raised levels of serotonin will cause elevated movement. This can contribute to diarrhea, bloating, and pain in patients with IBS.

Tianeptine decreases serotonergic function. Because of this, it improves the associated symptoms with IBS and non-ulcer dyspepsia.

In clinical trials, tianeptine is as effective as amitriptyline. Especially for the treatment of IBS-D.

In other trials with people with IBS-C or IBS-D, tianeptine improves their quality of life. But most importantly, symptoms resolve with tremendous results.

Potential Mechanisms of Action Concerning Depression Treatment

The primary mechanism responsible for treating depression occurs via glutamate receptor modulation. This includes AMPA and NMDA receptors. Consequently, it reverses stress-induced increases in the basolateral nucleus of the amygdala.

Tianeptine potentiates AMPA function in the pre-frontal cortex via GluR1 subunit phosphorylation. With this, we see a great reduction in symptoms. Tianeptine also activates delta-opioid and Mu-opioid receptors which are antidepressive.

Significant releases in BDNF are also noted. Tianeptine enhances serotonin reuptake. This means it helps the body to make use of serotonin beyond the cell bounds. 

It enhances the mesolimbic pleasure center of the body. Thus, tianeptine releases and potentiates the dopamine receptors.

Consequently, tianeptine increases a1-adrenergic system responsiveness, while reduction alpha-1 noradrenergic neurotransmission.  Thus, reducing the role of depressive illness in the person’s life. 

Finally, not certainly, tianeptine has the ability to increase norepinephrine.

Potential Mechanisms of Action Concerning Anxiety/Stress Treatment

Concerning anxiety treatment, tianeptine inhibits change in glutamatergic neurotransmission. Mostly in the amygdala and hippocampus. This means it indirectly adjusts the receptor activity, which results in neural plasticity.  

By normalizing the glutamate levels, it reverses stress-induced glutamate increase in the amygdala. But also inhibits glial transporters of glutamate.

This means it prevents the reorganization of synaptic vesicles in the hippocampus neurons. Thus, resulting in stress adaptation.

By enhancing serotonin reuptake, it soaks the neurotransmitter from without the cell. Tianeptine regulates prefrontal cortical and HPA axis activity in males. It also regulates glucocorticoid receptors in brains affected by maternal separation.

Another interesting method of action has to do with GABA concentration. This entails the route of GAD65 spinal cord expression.

This is accommodated by the activation of adenosine A1 receptors. This lowers the heart rate and helps anxiety. 

Additional Mechanisms of Action

In rats, the compound activates the mTORC1 pathway signaling and increases spine density. As well as dendritic outgrowth, and synaptic proteins by signaling mTORC1 in toxic conditions.

This normalizes the stress-induced change in the ratio of NMDA and kainate/AMPA receptor-mediated flow. As a result, neuroprotection occurs.

Furthermore, tianeptine inhibits stress-induced ratio re-scaling of NMDA to AMPA receptor excitatory postsynaptic current.

Like other antidepressants, tianeptine helps reverse the majority changes in insulin growth factor-1 of the animal olfactory bulb. With constant use, there is a change in the structure-dependent mitochondrial proteome in stressed brains.

Similar to other medications, tianeptine increases neuronal activity. This prevents glycine-induced ion flow and increasing the field potential. Tianeptine also induced CREB phosphorylation and NCAM140 expression.

The compound is also responsible for preventing B27 decreases in postsynaptic density protein-95. This happens alongside decreases in synaptophysin and BDNF levels. 

Tianeptine lowers the effect of dexamethasone proliferation and cell viability. It also prevents the uterine smooth muscle contraction.

This is supported by increases in glutathione catalase and peroxidase function. In uteri contraction, tianeptine reduces the SOD copper-zinc activity. 

As a final note, with tianeptine upstream action of dopaminergic neurons occurs. Via glycinergic and GABAergic inhibition of perikarya, tianeptine adjusts the dopaminergic levels.

Tianeptine Review And Summary

The information above does not mean much to most people. So individuals should do their own research. It’s the only way to ensure they comprehend at least the partial complexity of this compound.

In any case, some things are meant to be understood globally. This will help them decide if they would like to try tianeptine. All without spending time learning the scientific jargon.

Is Stablon/Coaxil/Tianeptine Effective?

Yes, tianeptine is quite effective. Especially when taken in the dosage and duration prescribed.

Skipping doses can depreciate the quality of effects. All side effects must be subject to importance at the earliest possibility.

Doctors will often suggest an approach to prevent or manage them. It can take several weeks to see serious improvement from symptoms. However, tianeptine has a reputation for resolving mood issues within an hour.

Treatment might need to be continued for extended periods of time to effectively treat your condition. This is best supported by a behavior therapy program to develop new patterns of thinking.

Are There Side Effects?

Tianeptine side effects are not common, but if they do occur, they resemble that of SSRIs. This includes constipation, abdominal pain, dizziness, nausea. But also headaches and dream change.

If you even experience mild symptoms, consult your doctor. Especially so if symptoms are persistent.

Older individuals should take smaller doses of the compound, this applies to patients with kidney failure as well. Dosages don’t have to be regulated for patients with hepatic impairment. The same applies to patients with dialysis or alcoholism.

Can One Abruptly Stop Consumption?

Never stop taking tianeptine abruptly especially if you think you can do without it. This can worsen your condition.

Continue taking the compound for the duration prescribed. And if you do decide to stop, cessate slowly following a protocol advised by a specialist. 

If you want to stop due to side effects, you should taper down slowly to avoid rebound effects. A gradual dose reduction will ensure you avoid withdrawal and addiction symptoms.

Can Pregnant Women Take Tianeptine?

Never take tianeptine if pregnant unless advised by a doctor.

It’s only clear that the benefits are outweighing the risks. But the risks affecting a developing baby are not worth the benefit. 

If you take this compound during the final trimester, it’s a serious problem. Your child might develop breathing problems. Blood pressure problems, irritability, spasms, and tremors are possible.

It’s advised that you consult with a specialist before taking this medicine. Especially if you are breastfeeding, pregnant, or want to get pregnant.

Do I Inform My Doctor Before Taking Tianeptine?

Before taking tianeptine, you should inform your doctor of all potential allergic reactions that you might have.

Inform the doctor of any problems with your thyroid, liver, kidneys, heart, or prostate. If you ever had a seizure, glaucoma, or diabetes, tell your doctor.

Inform your doctor of all medicines you might take. They may affect your experience with tianeptine.

If you are buying tianeptine without a prescription, that’s fine. Just make sure to visit a doctor in advance and discuss this. You need to cover all bases to ensure you don’t damage your health.

Tianeptine Warnings

It’s quite possible to develop an addiction or take a fatal dose of tianeptine. Tianeptine is addictive, both in terms of psychological and physiological dependence. People buying supplements without a prescription are more likely to abuse the substance. 

Tianeptine causes a euphoric effect that is comparable to opioids. This combined with tolerance development can cause individuals to adjust their dosages to feel the effects again. Tianeptine should never be taken more than 300 mg per day, and 100 mg per session.

Tianeptine Contraindications

In patients with bipolar symptoms and depression, tianeptine can worsen the mean scores that measure depressive symptoms. During pregnancy, tianeptine mimics opiate effects, often causing neonatal abstinence.

Tianeptine is also responsible for binge-drinking in adolescents. But the reverse is seen for adults. To ensure you avoid problems, you should consider visiting a doctor to discuss your interest in tianeptine.

Tell them about all the herbs, vitamins, and medications you take. Speak to your provider to discover how tianeptine can interact with your supplements. 

Is Tianeptine Worth It?

Considering that the side effects are minimal and mild, one should follow dosing guidelines.

One should also not adjust doses to accommodate for tolerance. And one should not abuse the drug recreationally. Tianeptine can change a person’s life for the better if done right.

If you believe that tianeptine can help you resolve your issues, good for you. But if you want it to heal your pains, speak to a doctor and discuss your interest. Be honest and if they cannot satisfy your interest, find another doctor.

They might choose to prescribe you the medicine, but that’s not always possible. 

If they believe that you are a good candidate for tianeptine, feel free to order it online. This can be done with reputable vendors with certificates of analysis.

Tianeptine Sodium/Sulfate for You

Now that you have read through our tianeptine review, you are much better off than the users who get into tianeptine without any previous knowledge of it.

In the world of medicine and nootropics, knowledge is king. Without knowing what you’re getting into, you risk your own health and that’s the opposite of what you want to achieve.

If you’re interested in purchasing tianeptine legally, certified high-quality with COAs, get in touch with us and we will happily accommodate your needs.

These products are not intended to diagnose, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product.

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