Tianeptine Sodium vs Sulfate: Choosing the Best One for You
Do you know what tianeptine is? Did you know it comes in two forms, tianeptine sodium, and tianeptine sulfate? If you didn’t, let’s get you up to date with the information you need to know.
In essence, tianeptine is a popular alternative for tricyclic antidepressants. But, it’s more infamous in the realm of nootropics for its mood-enhancing and cognitive benefits.
In this article, we will cover everything you need to know about tianeptine sodium vs sulfate. So that you can decide which one you would like to try for yourself.
If you’re ready to discover the miracle of tianeptine, keep reading.
What Is Tianeptine?
Stablon or Coaxil, also known as Tianeptine is a pharmaceutical compound that’s used primarily for the treatment of clinical depression. It’s also prescribed for the treatment of asthma and irritable bowel syndrome.
At large doses, it’s known to provide an opioid-like response in the body. These effects are stimulation, sedation, euphoria, and motivation enhancement. In terms of chemical structure, tianeptine is a tricyclic antidepressant.
In any case, the effects and pharmacology vary from the typical anxiolytic and antidepressant. Mainly because it’s not acting through the immediate regulation of monoaminergic neurotransmitters.
But it acts upon the glutamatergic and glutamate mechanisms. Thus, causing the brain to adapt better to scenarios of depression and stress.
Clinical trials suggest that’s it’s just as effective as other antidepressants. Similar to amitriptyline and fluoxetine. However, the substance does seem to present fewer side effects and complications, meaning it might be more effective.
Besides the antidepressant qualities, tianeptine also has anti-anxiety properties. Consequently showing promise in panic disorders.
Tianeptine improves cognition and has neuroprotective properties. The mood-boosting and anxiolytic effects with the cognitive and neuroprotective benefits make tianeptine popular nootropics.
In terms of guidelines, prescriptions indicate an average dose of 12.5 mg. It’s taken three times per day with at least 4 hours in between.
The Forms of Tianeptine: Tianeptine Sodium vs Sulfate
To get more specific on the use of tianeptine, we must examine the two primary forms in which it comes. If you already know which is better for your needs, you might as well skip this part. If you don’t, this section will help you decide.
It’s recommended that you try both even if you’re set on one. This will help you find which has the best effect in relation to your body chemistry.
Of the forms, tianeptine sodium stands out strongly with a big advantage. But it does have several disadvantages that might make it look like a bad choice.
The advantage of the sodium form is that the potency is substantially stronger. In fact, sodium is about twice as strong as sulfate. This is great for someone who looking for an immediate reaction (though short-lived).
The downside of sodium tianeptine is that’s difficult to store without depreciating its quality. Tianeptine sodium is sensitive to humidity, heat, light, and other elements. Most people suggest storage in a stainless steel container that has no air leaks.
The sulfate form generally has fewer disadvantages. But because it’s not as potent as the sodium form, the absorption rate is slower. That’s because tianeptine sodium is known for “immediate absorption”.
This can help with regulating your tianeptine levels throughout the day. This will ensure you avoid strikes and lulls. Sulfate is also easier to store and does not depreciate quickly.
This can help with regulating your tianeptine levels through the day, which will ensure you avoid strikes and lulls. Sulfate is also easier to store and does not depreciate quickly.
Keep in mind sulfate is still very effective and potent, it just happens to work differently in the body. Some suggest that sulfate absorbs into the body slower with a stable flow. Thus, increasing the amount of time for sustained effects to occur.
Sodium form requires smaller doses. The effects dissipate quite rapidly when compared to sulfate.
The Advantage Of Taking Tianeptine
Tianeptine is known to be as effective as traditional medication. It also focuses on improving mood, brain fog, and tiredness. But unlike regular medication, you don’t have to wait for entire cycles to feel an effect.
Tianeptine works by producing a subtle and considerable mood enhancement within minutes and has various cognitive beneficial effects. It has been shown that tianeptine can improve learning through the improvement of attention, short-term memory, and reaction time.
That’s tianeptine has become so popular among the nootropic communities, not just those who are looking to treat depression. For those suffering from it, tianeptine can be a life-saver.
Tianeptine is a very plausible option for individuals frustrated with the general medication experience, or those who want to see results quickly.
As mentioned, tianeptine is known to produce fewer side effects than antidepressant medications. Especially in the realm of sexual function.
Regular medications often induce sexual dysfunction. This can have a big impact on daily life.
It can cause feelings of embarrassment and frustration. Not to mention, the added stress in relationships.
Tianeptinetine can be the answer for many people. In 2003, a study of participants with depression who had antidepressant-induced dysfunction showed serious improvement when switching to tianeptine.
Which Is Better?
If you still haven’t decided which form of tianeptine is better, we’ll make it easy for you.
First, the sodium salts are very sensitive and not stable in atmospheric moisture. Sulfate salts are non-hygroscopic, non-cl, simply, and easy to handle.
Sulfate salts are soluble in water. This means their bioavailability is better than sodium. The taste of sodium is known to be bitter, while the sulfate form does not have much of a taste.
Sodium salts are effective in the short-term. The dosages must be subject to reduction to keep the effects stable. From a medical concern, this can lead to adherence depletion which reduced effectiveness.
Sulfate salts absorb slower. They take a substantial amount of time until the peak effect has been achieved.
This means dosing is not required regularly. Thus, solving one of the primary issues with sodium salts.
Unless you need short-lived and immediate tianeptine, the sulfate form is the obvious choice.
Unlike most antidepressants, tianeptine has practically no effects on the monoamine systems. Some of which are serotonin and dopamine. Tianeptine does affect extracellular dopamine levels, but there’s no known mechanism behind this.
Experiments done on rats reveal that tianeptine does not increase serotonin. In fact, it’s been found to increase serotonin reuptake. This is quite the opposite of prescribed medications. Most of them are selective serotonin reuptake inhibitors.
But the alteration of serotonin is most likely not related to the primary mechanism. Tianeptine contributes to neuroplasticity changes through the modulation of glutamate receptors. Most notably through indirect effects on NMDA.
Such changes in brain plasticity lead to decreases in depressive and stress symptoms. More recently, it’s discovered that tianeptine is also a great μ-opioid receptor agonist. This explains the overall effect profile.
Other Possibilities for Method of Action
Tianeptine normalized stress-induced change in the ratio of NMDA to AMPA receptor-mediated currents. This contributes to the neuroprotective qualities.
In rats, tianeptine activates mTORC1 signaling and improves dendritic outgrowth. Synaptic proteins and spine density are subject to this effect too. This happens under toxic conditions in the primary hippocampal neurons.
Tianeptine reverses most changes in insulin growth factor-1 in the olfactory bulb of animals. With constant use, there is a change in the structure-dependent mitochondrial proteome in the brain. It may also increase neuronal activity by reading the potential field by preventing glycine-induced ion flow.
Tianeptine induces CREB phosphorylation and NCAM140 expression. Tianeptine also prevents B27 deprivation decreases in postsynaptic density proteins, synaptophysin, and BDNF.
Tianeptine also lowers the effects of dexamethasone-caused viability and proliferation of cells. Tianeptine prevents uterine smooth muscle contractions and increases glutathione peroxidase and catalase.
In the contraction of uteri, tianeptine decreases activity in copper-zinc SOD. Assumptively, the upstream action of a dopaminergic neuron is subject to involvement. This is done via glycinergic inhibition of perikarya and tonic GABAergic.
Most of these things will not make sense to laymen, so it’s best that you take a term you don’t understand, and look for it in your search engine.
Harm Potential & Toxicity
This section is not to resemble absolute truth. It contains collective information from anecdotal and trialed sources. It’s advised that you conduct your own research to learn more.
In addition, you should make use of harm reduction protocols when taking tianeptine. The long-term health effects and toxicity of recreational use of tianeptine are not studied in a trialed context. The exact toxic dosage is not known.
Anecdotal evidence presumes that no negative effects lead to compound consumption at moderate doses in a sparing schedule. Independent research is essential to know if the compound is safe to consume in your situation.
The LD50 of this compound is not definitively established. But it does seem tianeptine has a large margin of safety therapeutic index.
The primary recommendation for tianeptine users is to never do so when consuming alcohol, before, du, ring, or after. The amount needed to overdose cannot be due to accidental exposure.
To ensure safety when using tianeptine, it’s advised to never exceed 300 mg in a single day or 100 mg in a single dosing session.
Addiction & Tolerance
Chronic use of this compound is mildly addictive. It can certainly cause psychological and physical dependence. When the physical aspects occur, withdrawal symptoms will be evident if the person stops their use suddenly.
Tolerance to the effects of tianeptine occurs over prolonged use, therapeutic effects included. This means that users will have to consume greater doses to achieve the same effect. To reduce tolerance, it takes anywhere from 3 to 7 to halve and about 2 weeks to baseline (as long as tianeptine consumption continues during).
This compound will cross-tolerance with opioids tricyclic antidepressants. Also, because of the short duration of effects, it might make it lucrative for users to redose. The euphoria from higher doses can cause individuals to exceed the advised dosages.
This will quickly intensify the negative effects and increase tolerance. Not to mention tianeptine has μ-opioid receptor agonist properties. This leads individuals to serious addiction and withdrawal mechanics.
Much like antidepressants, daily users of this compound should taper down their use instead of cutting it out. This will ensure that the symptoms of withdrawal are kept to their utmost minimum.
Tianeptine withdrawal is possible at doses as little as 500 mg per day. The likelihood increases with time spent consuming the drug and the daily dosage.
Withdrawal symptoms are flu-like. Watery nose and eyes, dry heaves are not uncommon. Emotional instability is also very likely.
Nonetheless, the withdrawal will be stronger than that of opioids. Mostly because of the combined mechanisms of action.
Tianeptine can be acquired with and without prescription. It’s prescribed in many Asian, European, and South American countries. It’s usually distributed under the trade names of Coaxil and Stablon.
In Canada, tianeptine is not subject to legal control. It’s legal to possess without a prescription or license. In Germany, it’s a prescription medication.
In Russia, tianeptine is a schedule duel III drug in the controlled substance act. In Switzerland, tianeptine is not a controller, it’s “legal”.
In the UK, tianeptine is illegal to supply, produce and import. It’s enforced with the Psychoactive Substance Act in effect.
In the US, tianeptine is not subject to federal control. Nootropic vendors ceased their sales due to the potential abuse and recreation use. In the state of Michigan, tianeptine sodium is a Schedule II controlled compound.
Purchase Tianeptine Safely
Now that you know what tianeptine, the differences between tianeptine sodium vs sulfate. You are well on your way to determining if you would like tianeptine for your own needs.
Keep in mind, tianeptine is not widely-researched. It’s best that you consult a medical specialist in advance. You can also read some published papers on a website like PubMed.
If you’re interested in purchasing either form of tianeptine safely with certificates of analysis to know that you’re getting exactly what you ordered, get in touch with us and we will happily accommodate your needs.